open sourceother

ESMFold v2

High-speed, high-accuracy protein folding model.

Developed by Meta AI

Official Site
2.5BParams
YesAPI Available
stableStability
1.0Version
MITLicense
PyTorchFramework
YesRuns Locally
Real-World Applications
  • Drug discoveryOptimized Capability
  • Protein designOptimized Capability
  • Structural biology researchOptimized Capability
  • Genomic data analysisOptimized Capability
Implementation Example
Example Prompt
Predict the 3D structure of a protein sequence: 'MKTAYIAKQRQISFVKSHFSRQDILD' with ESMFold v2.
Model Output
"3D structure file in PDB format representing the predicted structure of the input protein sequence."
Advantages
  • ✓ Faster structure predictions compared to its predecessor, enabling real-time applications in drug discovery.
  • ✓ Improved accuracy in fold predictions, enhancing reliability in structural biology experiments.
  • ✓ Open-source availability promotes collaborative research and rapid advancement within the scientific community.
Limitations
  • ✗ High computational resource requirements, which may limit accessibility for some users.
  • ✗ Complex setup process that may deter users lacking advanced technical expertise.
  • ✗ Potential limitations in predicting structures of very large proteins or complex protein complexes.
Model Intelligence & Architecture

Technical Documentation

ESMFold v2 leverages advanced deep learning techniques to predict the 3D structures of proteins with unprecedented speed and accuracy, making it an essential tool for researchers in structural biology, drug discovery, and related fields.

Technical Specification Sheet
Technical Details
Architecture
Transformer-based
Stability
stable
Framework
PyTorch
Signup Required
No
API Available
Yes
Runs Locally
Yes
Release Date
2025-05-25

Best For

Research institutions and biotech companies focused on protein structure and drug development.

Alternatives

AlphaFold 2, RoseTTAFold, RaptorX

Pricing Summary

Free and open-source under the MIT license.

Compare With

ESMFold v2 AlphaFold 2ESMFold v2 RoseTTAFoldESMFold v2 RaptorXESMFold v2 3D CNNs

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